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Mental health

Vortioxetine and your FAA medical

SSRI / 5-HT1A partial agonist antidepressant
Other names: Trintellix

FAA guidance

Do not issue.

Examiner

Do not issue: the examiner cannot issue a certificate

FAA label

UNACCEPTABLE

Source: FAA, Antidepressant Medications (table). FAA date 27 August 2025. Checked by Crosscheck 11 November 2026

The FAA lists vortioxetine as an unacceptable antidepressant.

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Show the FAA's words: vortioxetineThe official FAA wording: one passage, each with its document and dateOpen
FAA, Antidepressant Medications (table) · FAA date 27 August 2025
UNACCEPTABLE Antidepressant Medications (Used as a single agent or in any combination product.) — Selective Serotonin Reuptake Inhibitor/ 5-HT1A Receptor Partial Agonist: vortioxetine (Trintellix)
Sources and dates: vortioxetineOne FAA document, with the FAA's date and when Crosscheck checked itOpen

Questions pilots ask

Each answer is built from the FAA guidance on this page. Its sources and dates are in the page.

What does the FAA say about vortioxetine for pilots?

FAA guidance: Do not issue. The FAA lists vortioxetine as an unacceptable antidepressant. Crosscheck does not predict the FAA's decision.

What does the examiner do for vortioxetine?

Do not issue: the examiner cannot issue a certificate. Crosscheck does not predict the FAA's decision.

Related pages

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.