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Mental health

Tricyclic antidepressants and your FAA medical

Tricyclic antidepressant (TCA)
Other names: amitriptyline, Elavil, nortriptyline, Pamelor, imipramine, Tofranil

FAA guidance

Do not issue.

Examiner

Do not issue: the examiner cannot issue a certificate

FAA label

UNACCEPTABLE

Source: FAA, Antidepressant Medications (table). FAA date 27 August 2025. Checked by Crosscheck 11 November 2026

The FAA documents quoted here name the class, not this medication. Crosscheck matched it through its class: Tricyclic antidepressant (TCA).

The FAA's antidepressant table lists all tricyclic antidepressants (TCAs) as unacceptable.

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Compare FAA documents: Tricyclic antidepressantsWhat each of the two FAA documents says, in plain wordsOpen

Its migraine medication page also lists all tricyclic antidepressants as unacceptable for migraine prevention, prohibited as a single agent or in any combination product.

Show the FAA's words: Tricyclic antidepressantsThe official FAA wording: two passages, each with its document and dateOpen
FAA, Antidepressant Medications (table) · FAA date 27 August 2025
UNACCEPTABLE Antidepressant Medications (Used as a single agent or in any combination product.) — esketamine (Spravato) All tricyclic antidepressants (TCAs) All monoamine oxidase inhibitors (MAO-I)
FAA, Migraine Medication · FAA date 26 August 2026
UNACCEPTABLE – Migraine Prevention (Prophylaxis) Use prohibited as a single agent or in any combination product. ᴓ ALL tricyclic antidepressants (TCA)
Sources and dates: Tricyclic antidepressantsTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

Questions pilots ask

Each answer is built from the FAA guidance on this page. Its sources and dates are in the page.

What does the FAA say about tricyclic antidepressants for pilots?

FAA guidance: Do not issue. The FAA's antidepressant table lists all tricyclic antidepressants (TCAs) as unacceptable. Its migraine medication page also lists all tricyclic antidepressants as unacceptable for migraine prevention, prohibited as a single agent or in any combination product. Crosscheck does not predict the FAA's decision.

What does the examiner do for tricyclic antidepressants?

Do not issue: the examiner cannot issue a certificate. Crosscheck does not predict the FAA's decision.

Related pages

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.