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Tenapanor and your FAA medical

Sodium/hydrogen exchanger 3 inhibitor, on the FAA's colitis worksheet
Other names: Ibsrela

Taken for: Colitis: Crohn's disease, ulcerative colitis, microscopic colitis or irritable bowel syndromeTaking it for something else? The entries here do not cover that use. The FAA may address it in the guidance for your condition. Ask your examiner.

FAA guidance

Acceptable with conditions.

Examiner

CACI: the examiner can issue when the condition's worksheet criteria are met. Applicants for first- or second-class must provide the worksheet's information annually; applicants for third-class with each required exam

Source: FAA, CACI – Colitis Worksheet. FAA date 29 April 2026. Checked by Crosscheck 11 November 2026

For Crohn's disease, ulcerative colitis, microscopic colitis or irritable bowel syndrome, the FAA's CACI – Colitis Worksheet lists tenapanor (Ibsrela), a sodium/hydrogen exchanger 3 inhibitor, among the medications for the condition; any other cause of colitis requires an FAA decision.

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More detail: tenapanorThe rest of Crosscheck's reading, in plain wordsOpen

The worksheet applies with all its other criteria, and the examiner must note in Block 60 one of its statements, which include CACI qualified colitis, and not CACI qualified and deferred.

Show the FAA's words: tenapanorThe official FAA wording: one passage, each with its document and dateOpen
FAA, CACI – Colitis Worksheet · FAA date 29 April 2026
Cause of Colitis
Crohn’s disease, ulcerative colitis, microscopic colitis, or irritable bowel syndrome
Any other causes require an FAA decision.
Medications for condition
One or more of the following:
Sodium/Hydrogen Exchanger 3 Inhibitor
tenapanor (Ibsrela)
mercaptopurine (6-MP)
mesalamine (Asacol, Pentasa, Lialda)
AME MUST NOTE in Block 60 one of the following:
CACI qualified colitis. (Documents do not need to be submitted to the FAA.)
NOT CACI qualified. I have deferred. (Submit supporting documents.)
Sources and dates: tenapanorOne FAA document, with the FAA's date and when Crosscheck checked itOpen

Questions pilots ask

Each answer is built from the FAA guidance on this page. Its sources and dates are in the page.

What does the FAA say about tenapanor for pilots?

FAA guidance: Acceptable with conditions. For Crohn's disease, ulcerative colitis, microscopic colitis or irritable bowel syndrome, the FAA's CACI – Colitis Worksheet lists tenapanor (Ibsrela), a sodium/hydrogen exchanger 3 inhibitor, among the medications for the condition; any other cause of colitis requires an FAA decision. Crosscheck does not predict the FAA's decision.

What does the examiner do for tenapanor?

CACI: the examiner can issue when the condition's worksheet criteria are met. Applicants for first- or second-class must provide the worksheet's information annually; applicants for third-class with each required exam. Crosscheck does not predict the FAA's decision.

Related pages

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.