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Primidone and your FAA medical

Named on the FAA's essential tremor worksheet as not acceptable
Other names: Mysoline

FAA guidance

FAA review required.

Examiner

The examiner defers to the FAA

Source: FAA, CACI – Essential Tremor Worksheet. FAA date 26 July 2023. Checked by Crosscheck 11 November 2026

The FAA's CACI – Essential Tremor Worksheet says: "Gabapentin, primidone (Mysoline), and other potentially sedating medications are not acceptable for aeromedical purposes.

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Compare FAA documents: primidoneWhat each of the two FAA documents says, in plain wordsOpen

Do NOT CACI." It says a beta blocker is the only CACI-eligible medication for essential tremor.

The FAA's Tremor disposition table says the acceptable medication for CACI is none or a beta-blocker and all others go to its row C, which notes that most medication to treat tremor is not acceptable (for example gabapentin, mysoline [primadone]); for that row it says the examiner should defer and submit the information to the FAA for a possible special issuance.

Show the FAA's words: primidoneThe official FAA wording: two passages, each with its document and dateOpen
FAA, CACI – Essential Tremor Worksheet · FAA date 26 July 2023
Gabapentin, primidone (Mysoline), and other potentially sedating medications are not acceptable for aeromedical purposes. Do NOT CACI.
Note: Beta blocker is the ONLY CACI-eligible medication for this condition.
FAA, Essential Tremor · FAA date 25 January 2023
Acceptable medication for CACI is NONE or a beta-blocker. (All others go to Row C).
C. All others
Note: Most medication to treat tremor is not acceptable (e.g., gabapentin, mysoline [primadone]).
DEFER
Submit the information to the FAA for a possible Special Issuance
Sources and dates: primidoneTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

Questions pilots ask

Each answer is built from the FAA guidance on this page. Its sources and dates are in the page.

What does the FAA say about primidone for pilots?

FAA guidance: FAA review required. The FAA's CACI – Essential Tremor Worksheet says: "Gabapentin, primidone (Mysoline), and other potentially sedating medications are not acceptable for aeromedical purposes. Do NOT CACI." It says a beta blocker is the only CACI-eligible medication for essential tremor. Crosscheck does not predict the FAA's decision.

What does the examiner do for primidone?

The examiner defers to the FAA. Crosscheck does not predict the FAA's decision.

Related pages

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.