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Cholesterol

PCSK9 inhibitors and your FAA medical

Monoclonal antibody, PCSK9 inhibitor
Other names: alirocumab, Praluent, evolocumab, Repatha

FAA guidance

Acceptable with conditions.

Wait

48 hours

ground trial when starting

Examiner

The examiner can issue when the document's criteria are met

FAA label

ACCEPTABLE

Source: FAA, Cholesterol Medication. FAA date 27 August 2025. Checked by Crosscheck 11 November 2026

The FAA lists PCSK9 inhibitors as acceptable cholesterol medication, as a single agent or in any combination product, with the minimum standard 48-hour ground trial when starting.

Track your medications
More detail: PCSK9 inhibitorsThe FAA rules behind this answerOpen
  • 48 hours after starting: ground observation
Show the FAA's words: PCSK9 inhibitorsThe official FAA wording: one passage, each with its document and dateOpen
FAA, Cholesterol Medication · FAA date 27 August 2025
All drug classes require the minimum standard 48-hour initial ground trial. ACCEPTABLE Cholesterol Medications (as a single agent or in any combination product)
Monoclonal Antibody - PCSK9 Inhibitor: alirocumab (Praluent), evolocumab (Repatha).
Sources and dates: PCSK9 inhibitorsOne FAA document, with the FAA's date and when Crosscheck checked itOpen

Questions pilots ask

Each answer is built from the FAA guidance on this page. Its sources and dates are in the page.

What does the FAA say about PCSK9 inhibitors for pilots?

FAA guidance: Acceptable with conditions. The FAA lists PCSK9 inhibitors as acceptable cholesterol medication, as a single agent or in any combination product, with the minimum standard 48-hour ground trial when starting. Crosscheck does not predict the FAA's decision.

How long is the FAA's wait for PCSK9 inhibitors?

48-hour ground trial when starting.

What does the examiner do for PCSK9 inhibitors?

The examiner can issue when the document's criteria are met. Crosscheck does not predict the FAA's decision.

Related pages

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.