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Lifitegrast (ophthalmic) and your FAA medical

Lymphocyte Function-Associated Antigen 1 (LFA-1) Antagonist
Other names: Xiidra

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose

There is more to this wait.

Source: FAA, MedGuide (FAA Office of Aerospace Medicine medication reference). FAA date 27 October 2026. Checked by Crosscheck 11 November 2026

The FAA's MedGuide lists lifitegrast (ophthalmic) (Xiidra) as allowed, for dry eye disease, with a wait of 24 hours after the first dose; after each dose, no flying or safety-related duties while experiencing blurry vision or headache; and none after the final dose, used as prescribed.

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More detail: lifitegrast (ophthalmic)The rest of Crosscheck's reading, in plain wordsOpen

Wait

  • after each dose, no flying or safety-related duties while experiencing blurry vision or headache

The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present, and says wait times are not determined solely by the medication: an extended observation period may be required to verify clinical stability of the condition.

  • 24 hours after the first dose: ground observation
Show the FAA's words: lifitegrast (ophthalmic)The official FAA wording: three passages, each with its document and dateOpen
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
Generic: lifitegrast (ophthalmic)
Brand Name: Xiidra
Drug Class: Lymphocyte Function-Associated Antigen 1 (LFA-1) Antagonist
Underlying Condition: Dry eye disease
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): Do not fly or perform SRD while experiencing blurry vision or headache.
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: As prescribed
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
Underlying Condition: Evaluating medication use requires considering the impact of safety of flight from both the medication and underlying condition. Wait times are not determined solely by the medication; an extended observation period may be required to verify clinical stability of the condition.
Sources and dates: lifitegrast (ophthalmic)One FAA document, with the FAA's date and when Crosscheck checked itOpen

Questions pilots ask

Each answer is built from the FAA guidance on this page. Its sources and dates are in the page.

What does the FAA say about lifitegrast (ophthalmic) for pilots?

FAA guidance: Acceptable with conditions. The FAA's MedGuide lists lifitegrast (ophthalmic) (Xiidra) as allowed, for dry eye disease, with a wait of 24 hours after the first dose; after each dose, no flying or safety-related duties while experiencing blurry vision or headache; and none after the final dose, used as prescribed. Crosscheck does not predict the FAA's decision.

How long is the FAA's wait for lifitegrast (ophthalmic)?

24 hours after the first dose; after each dose, no flying or safety-related duties while experiencing blurry vision or headache.

Related pages

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.