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Cholesterol

Inclisiran and your FAA medical

Antilipemic Small Interfering Ribonucleic Acid (siRNA) Agent
Other names: Leqvio

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose

Different waits apply in other cases.

Source: FAA, MedGuide (FAA Office of Aerospace Medicine medication reference). FAA date 27 October 2026. Checked by Crosscheck 11 November 2026

The FAA's MedGuide lists inclisiran (Leqvio) as allowed, for hypercholesterolemia, with a wait of 24 hours after the first dose and 4 hours after each dose and the same after the final dose, used as prescribed.

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More detail: inclisiranThe rest of Crosscheck's reading, in plain wordsOpen

Wait

  • 4 hours after each dose
  • 4 hours after the final dose

The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present, and says wait times are not determined solely by the medication: an extended observation period may be required to verify clinical stability of the condition.

  • 24 hours after the first dose: ground observation
  • 4 hours after each dose: ground observation
  • 4 hours after stopping: ground observation
Show the FAA's words: inclisiranThe official FAA wording: three passages, each with its document and dateOpen
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
Generic: inclisiran
Brand Name: Leqvio
Drug Class: Antilipemic Small Interfering Ribonucleic Acid (siRNA) Agent
Underlying Condition: Hypercholesterolemia
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): 4 hours
DISCONTINUATION Wait Time (after final dose): Same as subsequent dose wait time
Frequency Use Limit: As prescribed
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
Underlying Condition: Evaluating medication use requires considering the impact of safety of flight from both the medication and underlying condition. Wait times are not determined solely by the medication; an extended observation period may be required to verify clinical stability of the condition.
Sources and dates: inclisiranOne FAA document, with the FAA's date and when Crosscheck checked itOpen

Questions pilots ask

Each answer is built from the FAA guidance on this page. Its sources and dates are in the page.

What does the FAA say about inclisiran for pilots?

FAA guidance: Acceptable with conditions. The FAA's MedGuide lists inclisiran (Leqvio) as allowed, for hypercholesterolemia, with a wait of 24 hours after the first dose and 4 hours after each dose and the same after the final dose, used as prescribed. Crosscheck does not predict the FAA's decision.

How long is the FAA's wait for inclisiran?

24 hours after the first dose; 4 hours after each dose; 4 hours after the final dose.

Related pages

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.