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Allergy and cold

Guaifenesin + pseudoephedrine and your FAA medical

Expectorant + Decongestant
Other names: Mucus-D, Duratuss GP, Entex

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose

Source: FAA, MedGuide (FAA Office of Aerospace Medicine medication reference). FAA date 27 October 2026. Checked by Crosscheck 11 November 2026

The FAA's MedGuide lists guaifenesin + pseudoephedrine (Mucus-D, Duratuss GP, Entex) as allowed, for allergic rhinitis or congestion, with a wait of 24 hours after the first dose and none after later doses or after the final dose, used per label directions.

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More detail: guaifenesin + pseudoephedrineThe rest of Crosscheck's reading, in plain wordsOpen

The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present, and says wait times are not determined solely by the medication: an extended observation period may be required to verify clinical stability of the condition.

  • 24 hours after the first dose: ground observation
Show the FAA's words: guaifenesin + pseudoephedrineThe official FAA wording: three passages, each with its document and dateOpen
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
Generic: guaiFENesin + pseudoephedrine
Brand Name: Mucus-D; Duratuss GP [INTL]; Entex [INTL]
Drug Class: Expectorant + Decongestant
Underlying Condition: Allergic rhinitis; Congestion
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: Per label directions
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 27 October 2026
Underlying Condition: Evaluating medication use requires considering the impact of safety of flight from both the medication and underlying condition. Wait times are not determined solely by the medication; an extended observation period may be required to verify clinical stability of the condition.
Sources and dates: guaifenesin + pseudoephedrineOne FAA document, with the FAA's date and when Crosscheck checked itOpen

Questions pilots ask

Each answer is built from the FAA guidance on this page. Its sources and dates are in the page.

What does the FAA say about guaifenesin + pseudoephedrine for pilots?

FAA guidance: Acceptable with conditions. The FAA's MedGuide lists guaifenesin + pseudoephedrine (Mucus-D, Duratuss GP, Entex) as allowed, for allergic rhinitis or congestion, with a wait of 24 hours after the first dose and none after later doses or after the final dose, used per label directions. Crosscheck does not predict the FAA's decision.

How long is the FAA's wait for guaifenesin + pseudoephedrine?

24 hours after the first dose.

Related pages

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.